Alcohol, liver and genes: an intricate puzzle

Alcohol, liver and genes: an intricate puzzle.

Critical Review Yeast Programmed Cell Death: An Intricate Puzzle

Yeasts as eukaryotic microorganisms with simple, well known and tractable genetics, have long been powerful model systems for studying complex biological phenomena such as the cell cycle or vesicle fusion. Until recently, yeast has been assumed as a cellular ‘clean room’ to study the interactions and the mechanisms of action of mammalian apoptotic regulators. However, the finding of an endogeno...

miRNAs, Melanoma and Microenvironment: An Intricate Network

miRNAs are central players in cancer biology and they play a pivotal role in mediating the network communication between tumor cells and their microenvironment. In melanoma, miRNAs can impair or facilitate a wide array of processes, and here we will focus on: the epithelial to mesenchymal transition (EMT), the immune milieu, and metabolism. Multiple miRNAs can affect the EMT process, even at a ...

mTOR, AMBRA1, and autophagy: An intricate relationship

Autophagy is the primary catabolic cellular degradation process, which generates nutrients and energy to maintain essential cellular activities upon nutrient starvation. The regulation of autophagy is central to the understanding of its mechanisms; post-translational modifications account for the rapid kinetics that control autophagy induction. A recent paper of ours provided 2 important insigh...

lncRNAs and MYC: An Intricate Relationship

Long non-coding RNAs (lncRNAs) are emerging as important regulators of gene expression networks, acting either at the transcriptional level, by influencing histone modifications, or at the post-transcriptional level, by controlling mRNA stability and translation. Among the gene expression networks known to influence the process of oncogenic transformation, the one controlled by the proto-oncoge...